Since World War II the concept of Information has received several new definitions. Information can be understood as knowledge in general, as theoretical, formalized knowledge in general or as knowledge related to specific domains or specific representational forms. Because of these mutually inconsistent concepts the common traits are to be found in a perspective transcendent to those theories. The central cultural changes, it is argued, take place on the level of the societal knowledge infrastructure, evolving from the knowledge infrastructure of the industrial societies as a long-term secularization process, resulting in new forms for representation and manipulation of knowledge. The process is seen as rooted in changes of the primary domains for knowledge extraction and in a change in the human relations to the languages in which we interpret the relations to nature.