This introduction presents the set of six articles, written by rhetorical scholars, which constitute the bulk of the present special issue of Argumentation. In the introduction, the issue editor seeks to identify defining features of a rhetorical approach to argumentation. Taking this approach means dealing with argumentation in the “realm of rhetoric” (a term from C. Perelman), which comprises argumentation where deductive “demonstration” is not available. This has several corollaries, including the condition of uncertainty and the necessity of securing adherence from an audience. The articles in the issue explore these and other characteristics of argumentation in the realm of rhetoric.