In the foundational texts on schizophrenia, the mental disorder was constitutively linked to a certain disintegration of subjectivity (often termed ‘self-disorder’). Apart from Scharfetter’s work on ego-pathology, self-disorders generally faded into oblivion and were only rediscovered as important psychopathological features of the schizophrenia spectrum nearly two decades ago. Subsequently, the EASE: Examination of Anomalous Self-Experience scale was constructed to allow systematic assessment of non-psychotic self-disorders. This study presents the first systematic review of empirical studies on self-disorders based on the EASE or related scales. The results consistently demonstrate that self-disorders hyper-aggregate in schizophrenia spectrum disorders but not in other mental disorders; that self-disorders are found in individuals at clinical risk of developing psychosis; that self-disorders exhibit a high degree of temporal stability; that self-disorders predict later cases of schizophrenia spectrum disorders; and that self-disorders correlate with the canonical dimensions of the psychopathology of schizophrenia, impaired social functioning, and suicidality. Methodological issues pertaining to the reviewed literature are critically discussed and the role of self-disorders in clinical psychiatry and future research is outlined.